Despite the overwhelmingly negative impacts of substance use stigma, little is known about how multiple, overlapping stigmatized identities, experiences, or characteristics (henceforth stigmas) may be related to perceived substance use stigma, especially in a sample of women who are incarcerated. This study profiled stigmas reported by women in jail with substance use histories and investigated the relationship between the number of overlapping stigmas reported and perceptions of substance use stigma.